Bala Govind (Allu Arjun) is a program director in a private TV channel. In one of his adventures, he enters in to a tussle with a local goon, Ponnu Swamy (Pradeep Rawat). When Ponnu Swamy gang is after Bala Govind, the TV channel sends him to Kulu Manali to shoot a program on Sanyasins there. There he meets a sanyasin Vaishali (Hansika Motwani) and falls in love with her. Rest of the story is about how he wins her hand.
Desamuduru is the immediate next film of Puri Jagannath after Pokiri. The songs of the movie struck the chord of the masses and therefore, expectations over the movie shot up. The movie opened up to a mixed talk initially but the openings were the highest for an Allu Arjun movie. Finally it ended up as an average grosser.