Television:
The filmy blood in Lakshmi automatically directed her towards the glam world. During her stay in US, she donned the first grease paint for American Television series, Las Vegas in which she played the role of Sarasvati Kumar, the love interest of James Lesure. Later she went on to play several TV shows like Boston Legal, Mystery ER and Desperate Housewives.

Once she is back in India, she started a celebrity talk show called Lakshmi Talk Show. It was hugely popular on TV and she became a recognizable face throughout the state with it. Later on she worked out similar kind of shows, Prematho Mee Lakshmi and Lakkunte Lakshmi which were also successful. Her most recent TV show, Doosukeltha is currently being aired and the first few episodes indicate a big success for Lakshmi.

Filmy Career:

As Actor and Producer:
Lakshmi Manchu started her career with some little roles in English movies, The Ode and Dead Air. In 2006, she acted, directed, and produced a short film ‘Perfect Lives’ that was showcased at the Wilshire Fine Arts Theater as part of the La Femme Film Festival in Los Angeles. Back in India, she started producing films. She produced Manchu Manoj starrer Nenu Meeku Telusa? and Jhummandhi Nadham but both the movies did not do well at the box office.

She made her acting debut in Telugu with a negative role of Irendri in Anaganga O dheerudu (2011). She played an evil witch in the movie and her performance in the movie was appreciated by one and all. She even went on to bag Nandi award for her excellent performance in the movie. In the same year, she acted in Dongala Muta, a film directed by Ram Gopal Varma. The director wrapped up the movie shooting under 5 days which was a record for any Telugu movie. Unfortunately, both the movies failed at the box office.

In 2012, Lakshmi made her Bollywood debut with Ram Gopal Varma’s Department which was yet again a failure. In the same year, she also produced Nandamuri Balakrishna and Manchu Manoj’s Uu Kodathara Ulikki Padathara. She acted in a little role in the movie as a beggar woman, a role which none of the contemporaries’ even think of trying. But she pulled it off with flying colours. But the commercial result of the movie once again disappointed her.

Finally after a lot of hard work and waiting, her first success came in 2013. Lakshmi acted and produced Gundello Godari. She acted as an innocent village belle in the movie and it turned out to be a decent hit. The movie was simultaneously made in Tamil as Maranthen Mannithe but did not do well there.  Her most recent film is Chandamama Kathalu in which she plays a falling model who struggles to come up with terms of live. The actress was seen in a very bold character using cuss words and also resorted to smoking and drinking

Short Films:
Lakshmi Manchu just acted in one short film till date and incidentally it is also the first Short Film by Ram Gopal Varma. The short film titled ‘A day in the life of Lakshmi Manchu's feet'. The short film is all about the busy schedule of Lakshmi’s feet in a day. However the short film failed to evince much interest from film enthusiasts and Netizens.